Apicobasal polarity complexes
نویسندگان
چکیده
منابع مشابه
Apicobasal polarity complexes.
Asymmetric distribution of proteins and other molecules within cells leads to cell polarization. One of the most studied examples occurs in epithelial cells that polarize to form apical and basolateral surfaces (Nelson, 2003). Although we know much about directed protein trafficking after cells are polarized, less is known about the initial mechanisms that lead to polarization. Genetic and bioc...
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Cell polarization and cell division are two fundamental cellular processes. The mechanisms that establish and maintain cell polarity and the mechanisms by which cells progress through the cell cycle are now fairly well understood following decades of experimental work. There is also increasing evidence that the polarization state of a cell affects its proliferative properties. The challenge now...
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Multiple intestinal atresia (MIA) is a rare cause of bowel obstruction that is sometimes associated with a combined immunodeficiency (CID), leading to increased susceptibility to infections. The factors underlying this rare disease are poorly understood. We characterized the immunological and intestinal features of 6 unrelated MIA-CID patients. All patients displayed a profound, generalized lym...
متن کاملApicobasal polarity and its role in cancer progression.
Abstract Appropriate establishment and maintenance of cell polarity is essential for normal development and homeostasis. The vast majority of human cancers originate from epithelial tissues and tumour cell invasion and metastasis are the major cause of mortality in human cancers. Invading cells demonstrate loss of cell polarity, loss of epithelial cell-cell adhesions and tissue disorganisation....
متن کاملThe interdependence of the Rho GTPases and apicobasal cell polarity
Signaling via the Rho GTPases provides crucial regulation of numerous cell polarization events, including apicobasal (AB) polarity, polarized cell migration, polarized cell division and neuronal polarity. Here we review the relationships between the Rho family GTPases and epithelial AB polarization events, focusing on the 3 best-characterized members: Rho, Rac and Cdc42. We discuss a multitude ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2005
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.02597